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Apr 20, 2024
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BIOL 454 - Genomic Conflict, Epigenetics & Human Disease (3 units)
Survey of agents of genomic conflict and non-Mendelian genetic mechanisms, with emphasis on their implications for phenotypic disruption and human disease.
Prerequisite(s): BIOL 190 ; BIOL 191 .
Units of Lecture: 3
Offered: Every Fall
Student Learning Outcomes:
Upon completion of this course:
1. Students will be able to distinguish between the co-adapted and counter-adapted views of organismal genomes.
2. Students will be able to compare and contrast the characteristics of prokaryotic and eukaryotic genomes.
3. Students will be able to identify and describe agents of genomic conflict.
4. Students will be able to describe the mechanisms of epigenetic gene regulation and techniques used for studying those mechanisms.
5. Students will be able to explain the role of epigenetic gene regulation in development and the importance of epigenetic change in disease, phenotypic variation, reproduction and aging.
6. Students will be able to discuss the sensitivity of epigenomes to environmental factors and potential mechanisms for the inheritance of acquired epigenetic states.
7. Students will be able to discuss epigenetic therapy in the treatment of disease.
8. Students will be able to define other forms of non-mendelian inheritance (paramutation, meiotic drive, feto-maternal cell trafficking and maternal inheritance) and discuss their phenotypic and evolutionary consequences.
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