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Apr 20, 2025
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PHAR 710 - Molecular Pharmacology (3 units)
Current understanding of drug-receptor interactions in mammalian systems including: molecular structure of receptors, ligand binding interactions, transduction of receptor signals, and receptors as pharmaceutical targets. (Intended for Molecular Biosciences graduate students pursuing a specialization in pharmacology.)
Units of Lecture: 3
Offered: Every Fall
Student Learning Outcomes
Upon completion of this course, students will be able to:
1. demonstrate understanding of the molecular biochemistry of receptor structure and principles governing ligand-receptor binding interactions, pharmacokinetics and pharmacodynamics.
2. recognize the molecular pharmacology of transduction of the receptor signal with specific considerations for drug interactions with receptors, ion channels and genes as pharmaceutical targets.
3. critically appraise original scientific literature related to molecular pharmacology and develop new ideas and experimental approaches that would contribute in expanding this area.
4. recognize the basic concepts involved in drug discovery including assay development, drug libraries, Lipinski criteria for drugs, high throughput drug screen, high content drug screen, secondary screens, hit validation and hit-to-lead optimization.
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