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Apr 20, 2024
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BIOL 454 - Genomic Conflict, Epigenetics & Human Disease (3 units)
Survey of agents of genomic conflict and non-Mendelian genetic mechanisms, with emphasis on their implications for phenotypic disruption and human disease.
Prerequisite(s): BIOL 190A ; BIOL 191A .
Grading Basis: Graded
Units of Lecture: 3
Offered: Every Fall
Student Learning Outcomes
Upon completion of this course, students will be able to:
1. distinguish between the co-adapted and counter-adapted views of organismal genomes.
2. compare and contrast the characteristics of prokaryotic and eukaryotic genomes.
3. identify and describe agents of genomic conflict.
4. describe the mechanisms of epigenetic gene regulation and techniques used for studying those mechanisms.
5. explain the role of epigenetic gene regulation in development and the importance of epigenetic change in disease, phenotypic variation, reproduction and aging.
6. discuss the sensitivity of epigenomes to environmental factors and potential mechanisms for the inheritance of acquired epigenetic states.
7. discuss epigenetic therapy in the treatment of disease.
8. define other forms of non-mendelian inheritance (paramutation, meiotic drive, feto-maternal cell trafficking and maternal inheritance) and discuss their phenotypic and evolutionary consequences.
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