MLS 607L - Immunohematology Laboratory

(1 unit)

Study of blood banking and transfusion medicine with emphasis on immunologic principles. Topics include donor screening, component therapy, ABO/Rh and other blood group systems, pre-transfusion and compatibility testing, and antibody identification. Covers HDFN, neonatal/obstetrical transfusions, autoimmune hemolytic anemias, and transfusion reactions. Focus on safety, quality, and clinical application

Maximum units a student may earn: 1

Prerequisite(s): MLS 605 and MLS 606

Grading Basis: Graded
Units of Laboratory/Studio: 1
Offered: Every Spring

Student Learning Outcomes
Upon completion of this course, students will be able to:
1. demonstrate proper specimen handling, labeling, and storage in accordance with transfusion safety protocols and evaluate sample for suitability for testing.
2. perform ABO and Rh typing using forward and reverse methods, resolving discrepancies when necessary.
3. carry out antibody screening using gel, tube, or solid-phase methodologies and interpret the results.
4. identify antibodies using comprehensive panel interpretation with attention to enhancement media, dosage, and phase reactivity.
5. perform crossmatches using immediate spin, antiglobulin (IAT), and electronic methods with appropriate interpretation.
6. resolve technical discrepancies including mixed field agglutination, rouleaux, and autoantibody interference.
7. conduct direct antiglobulin testing (DAT) and interpret findings related to autoimmune hemolytic anemia and HDFN.
8. describe the use of elution and adsorption techniques in resolving complex cases involving autoantibodies or multiple alloantibodies.
9. apply and document quality control procedures including reagent QC, equipment checks, and corrective actions.
10. describe immunohematology automation and assess its performance against manual methods for accuracy and reliability.
11. identify pre-analytical, analytical and post-analytical causes of error in laboratory testing.

Click here for course scheduling information. | Check course textbook information