BIOL 453 - Immunology

(3 units)

Organization, development, and regulation of the immune system, antibody structure and function, cellular and humoral effector mechanisms in immunity, and immunologic mechanisms in disease. (BIOL 453 and MICR 453 are cross-listed; credit may be earned in one of the two.)

Prerequisite(s): BIOL 300 or BIOL 304 or BIOL 315.

Grading Basis: Graded
Units of Lecture: 3
Offered: Every Fall

Student Learning Outcomes
Upon completion of this course, students will be able to:
1. recognize the various innate immune mechanisms that provide initial defense against pathogenic organisms.
2. describe how innate immunity provides the signals for initiating adaptive immunity.
3. describe the development of T and B lymphocytes, and explain the genetic basis for generation of antigen receptor diversity.
4. compare and contrast the recognition of antigen by T and B lymphocytes, and define the role of the major histocompatibility complex.
5. discuss the role of cell-mediated and humoral immune defense mechanisms against pathogens.
6. explain how microbes avoid immune defenses, and describe various primary and acquired immunodeficiencies.
7. demonstrate an understanding of how the principles of allergy and hypersensitivity diseases, autoimmunity, transplantation, immunoregulation, tumor immunology, and vaccination.

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